Recombinant Human leukocyte cell derived chemotaxin 1, His-tagged

• Cat.No.: LECT1-426H
• Product Overview: LECT1, 214-334aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 214-334 a.a.
• Description: LECT1 is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Recombinant human LECT1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
• Molecular Mass: 16.3kDa (141aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSREVVRKI VPTTTKRPHS GPRSNPGAGR LNNETRPSVQ EDSQAFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL GGYYPWPYNY QGCRSACRVI MPCSWWVARI LGMV
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: LECT1 leukocyte cell derived chemotaxin 1 [ Homo sapiens ]
• Official Symbol: LECT1
• Synonyms: LECT1; leukocyte cell derived chemotaxin 1; multiple myeloma tumor suppressor 1 , MYETS1; leukocyte cell-derived chemotaxin 1; CHM I; CHM1; chondromodulin; chondromodulin I; chondromodulin-1; chondromodulin-I; BRICHOS domain containing 3; multiple myeloma tumor suppressor 1; CHM-I; BRICD3; MYETS1
• Gene ID: 11061
• mRNA Refseq: NM_001011705
• Protein Refseq: NP_001011705
• MIM: 605147
• UniProt ID: O75829
• Chromosome Location: 13q14.3