Recombinant Human Lectin, Galactoside-binding, Soluble, 4

• Cat.No.: LGALS4-1802H
• Product Overview: Recombinant human Galectin-4 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 38.1 kDa (343aa).

Specification

• Cat. No.: LGALS4-1802H
• Description: Galectin-4 belongs to a subfamily of galectins composed of two carbohydrate recognition domains within the same peptide chain. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic reactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer.
• Source: E.coli.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR LSAFQRVDTL EIQGDVTLSY VQI
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Tag: Non

Gene Information

• Gene Name: LGALS4 lectin, galactoside-binding, soluble, 4 [ Homo sapiens ]
• Synonyms: LGALS4; lectin, galactoside-binding, soluble, 4; GAL4; L36LBP; galectin-4; galectin 4; lactose-binding lectin 4; L-36 lactose-binding protein;Antigen NY-CO-27
• Gene ID: 3960
• mRNA Refseq: NM_006149
• Protein Refseq: NP_006140
• MIM: 602518
• UniProt ID: P56470
• Chromosome Location: 19q13.2
• Function: protein binding; sugar binding

Reviews

08/18/2022

Its versatility and consistent performance make it an indispensable tool for a wide range of research applications.

11/01/2020

This exceptional clarity allows for accurate quantification and analysis, contributing to the overall success of my research endeavors.

07/28/2017

When used in Western Blotting experiments, the LGALS4 protein consistently generates clear and distinct protein bands.

Q&As

How is LGALS4 involved in cancer progression?

LGALS4 is often overexpressed in certain cancers and is associated with tumor growth, invasion, and metastasis, making it a potential biomarker for cancer diagnosis and prognosis.

Can LGALS4 be targeted for therapeutic intervention in autoimmune diseases?

Studies suggest that modulating LGALS4 expression or activity may have therapeutic potential in managing autoimmune diseases by regulating immune responses.

Is LGALS4 involved in neurodegenerative disorders?

Emerging research indicates that LGALS4 may play a role in neurodegenerative disorders, making it a target for further investigation in conditions like Alzheimer's disease.

How does LGALS4 contribute to inflammation and immune responses?

LGALS4 is involved in modulating immune responses and inflammation, suggesting its potential as a therapeutic target for inflammatory diseases.

Can LGALS4 be used as a diagnostic marker for cancer?

Research suggests that elevated levels of LGALS4 may serve as a diagnostic marker for certain cancers, aiding in early detection.