Recombinant Human LCK, GST-tagged, Active

• Cat.No.: LCK-342H
• Product Overview: Recombinant full-length human LCK was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 84 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: LCK (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ]
• Synonyms: LCK; lymphocyte-specific protein tyrosine kinase; YT16; p56lck; pp58lck; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; EC 2.7.10.2; LSK; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase
• Gene ID: 3932
• mRNA Refseq: NM_001042771
• Protein Refseq: NP_001036236
• MIM: 153390
• UniProt ID: P06239
• Chromosome Location: 1p34.3
• Pathway: Natural killer cell mediated cytotoxicity; Primary immunodeficiency; T cell receptor signaling pathway; HIV Infection; HIV Infection; Signaling in Immune system
• Function: non-membrane spanning protein tyrosine kinase activity; ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; SH2 domain binding; glycoprotein binding; nucleotide binding; phosphoinositide 3-kinase binding; protein C-terminus binding; protein kinase binding; protein serine/threonine phosphatase activity; transferase activity