Active Recombinant Human KMT2E protein, GST-tagged
Cat.No. : | KMT2E-192H |
Product Overview : | Recombinant Human KMT2E(1-548 aa) fused with GST tag at N-terminal was expressed in Insect cells. |
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Species : | Human |
Source : | Insect Cells |
Tag : | GST |
Protein Length : | 1-548 aa |
Description : | Mixed-lineage leukemia protein 5 (MLL5) plays a key regulatory role in hematopoiesis by mediating mono- or demethylation of lysine-4 of histone H3. MLL5 can associate with host cell factor-1 (HCF-1) and be recruited to E2F1-responsive promoters, and thus promotes cell cycle progression. Isoform NKp44L acts as cellular ligand for a natural cytotoxicity receptor, which is critical for NK cell-mediated innate immunity. |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 250 nmol/min/mg |
Molecular Mass : | 100 kDa |
Purity : | >90% |
Applications : | Methyltransferase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name | KMT2E lysine methyltransferase 2E [ Homo sapiens ] |
Official Symbol | KMT2E |
Synonyms | MLL5; NKp44L; HDCMC04P; histone-lysine N-methyltransferase MLL5; lysine (K)-specific methyltransferase 2E; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein 5 |
Gene ID | 55904 |
mRNA Refseq | NM_182931 |
Protein Refseq | NP_891847 |
UniProt ID | Q8IZD2 |
Chromosome Location | 7q22.3 |
Pathway | Chromatin modifying enzymes, organism-specific biosystem; Lysine degradation, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem |
Function | enzyme binding; transcription coactivator activity; zinc ion binding |
◆ Recombinant Proteins | ||
KMT2E-192H | Active Recombinant Human KMT2E protein, GST-tagged | +Inquiry |
KMT2E-4346H | Recombinant Human KMT2E protein, His&Myc-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
KMT2E-1116HCL | Recombinant Human KMT2E cell lysate | +Inquiry |
Not For Human Consumption!
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