Active Recombinant Human KMT2E protein, GST-tagged

• Cat.No.: KMT2E-192H
• Product Overview: Recombinant Human KMT2E(1-548 aa) fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 1-548 aa
• Description: Mixed-lineage leukemia protein 5 (MLL5) plays a key regulatory role in hematopoiesis by mediating mono- or demethylation of lysine-4 of histone H3. MLL5 can associate with host cell factor-1 (HCF-1) and be recruited to E2F1-responsive promoters, and thus promotes cell cycle progression. Isoform NKp44L acts as cellular ligand for a natural cytotoxicity receptor, which is critical for NK cell-mediated innate immunity.
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 250 nmol/min/mg
• Molecular Mass: 100 kDa
• Purity: >90%
• Applications: Methyltransferase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: KMT2E lysine methyltransferase 2E [ Homo sapiens ]
• Official Symbol: KMT2E
• Synonyms: MLL5; NKp44L; HDCMC04P; histone-lysine N-methyltransferase MLL5; lysine (K)-specific methyltransferase 2E; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein 5
• Gene ID: 55904
• mRNA Refseq: NM_182931
• Protein Refseq: NP_891847
• UniProt ID: Q8IZD2
• Chromosome Location: 7q22.3
• Pathway: Chromatin modifying enzymes, organism-specific biosystem; Lysine degradation, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
• Function: enzyme binding; transcription coactivator activity; zinc ion binding