Active Recombinant Human KMT2E protein, GST-tagged

Cat.No. : KMT2E-192H
Product Overview : Recombinant Human KMT2E(1-548 aa) fused with GST tag at N-terminal was expressed in Insect cells.
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Species : Human
Source : Insect Cells
Tag : GST
Protein Length : 1-548 aa
Description : Mixed-lineage leukemia protein 5 (MLL5) plays a key regulatory role in hematopoiesis by mediating mono- or demethylation of lysine-4 of histone H3. MLL5 can associate with host cell factor-1 (HCF-1) and be recruited to E2F1-responsive promoters, and thus promotes cell cycle progression. Isoform NKp44L acts as cellular ligand for a natural cytotoxicity receptor, which is critical for NK cell-mediated innate immunity.
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 250 nmol/min/mg
Molecular Mass : 100 kDa
Purity : >90%
Applications : Methyltransferase Assay
Stability : 1 year at -70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name KMT2E lysine methyltransferase 2E [ Homo sapiens ]
Official Symbol KMT2E
Synonyms MLL5; NKp44L; HDCMC04P; histone-lysine N-methyltransferase MLL5; lysine (K)-specific methyltransferase 2E; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein 5
Gene ID 55904
mRNA Refseq NM_182931
Protein Refseq NP_891847
UniProt ID Q8IZD2
Chromosome Location 7q22.3
Pathway Chromatin modifying enzymes, organism-specific biosystem; Lysine degradation, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
Function enzyme binding; transcription coactivator activity; zinc ion binding

Not For Human Consumption!

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