Recombinant Human KMT2B Complex, His-tagged

• Cat.No.: KMT2B-131H
• Product Overview: Recombinant Human MLL4 (2490-2715), WDR5 (22-334), RbBP5 (1-538), Ash2L (2-534), DPY-30 (1-99) protein, fused with N-terminal His-tag on all subunits, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: 2490-2715;22-334;1-538;2-534;1-99 a.a.
• Form: 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl2.
• Molecular Mass: 211.0 kDa
• Storage: Store at -80°C. Thaw quickly and store on ice before use. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: KMT2B lysine (K)-specific methyltransferase 2B [ Homo sapiens ]
• Official Symbol: KMT2B
• Synonyms: HRX2; MLL2; MLL4; TRX2; WBP7; MLL1B; WBP-7; CXXC10; WW domain binding protein 7; histone-lysine N-methyltransferase MLL4; mixed lineage leukemia gene homolog 2; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4; myeloid/lymphoid or mixed-lineage leukemia protein 4; trithorax homologue 2
• Gene ID: 9757
• mRNA Refseq: NM_014727
• Protein Refseq: NP_055542
• MIM: 606834
• UniProt ID: Q9UMN6
• Chromosome Location: 19q13.1
• Pathway: Chromatin modifying enzymes, organism-specific biosystem; Lysine degradation, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
• Function: histone methyltransferase activity (H3-K4 specific); protein binding; transcription factor activity, sequence-specific DNA binding