Recombinant Human KLK8 protein, His & T7-tagged

• Cat.No.: KLK8-797H
• Product Overview: Recombinant Human KLK8 aa. (Gln29~Gly260 (Accession # O60259)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Gln29~Gly260
• Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
• Form: Freeze-dried powder
• Molecular Mass: 34kDa as determined by SDS-PAGE reducing conditions.
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >90%
• Characteristic: The isoelectric point is 6.1.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: KLK8 kallikrein related peptidase 8 [ Homo sapiens (human) ]
• Official Symbol: KLK8
• Synonyms: NP; HNP; NRPN; PRSS19; TADG14; ovasin; serine protease 19; serine protease TADG-14; tumor-associated differentially expressed gene 14 protein; kallikrein-8
• Gene ID: 11202
• mRNA Refseq: NM_001281431.1
• Protein Refseq: NP_001268360.1
• UniProt ID: O60259