Recombinant Human KLB, Fc-tagged

• Cat.No.: KLB-537H
• Product Overview: The extracellular domain of human βKlotho (aa 1-996) is fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 1-996 a.a.
• Description: βKlotho (KLB) induces ERK1/2 phosphorylation in response to FGF19 treatment and significantly increases the interactions between FGF19 and FGFR4. It is a cofactor for the interaction of FGF21 with FGF receptor 1c in adipocytes, which allows FGF21 to stimulate GLUT1 expression, upregulating adipocyte insulin-dependent glucose uptake. bKlotho contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis.
• Form: Liquid. 0.2μm-filtered solution in PBS.
• Molecular Mass: ~180kDa (SDS-PAGE)
• Purity: ≥95% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Concentration: 0.05mg/ml

Gene Information

• Gene Name: KLB klotho beta [ Homo sapiens ]
• Official Symbol: KLB
• Synonyms: KLB; klotho beta; beta-klotho; betaKlotho; klotho beta like; klotho beta-like protein; BKL; MGC142213
• Gene ID: 152831
• mRNA Refseq: NM_175737
• Protein Refseq: NP_783864
• MIM: 611135
• UniProt ID: Q86Z14
• Chromosome Location: 4p14
• Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem
• Function: catalytic activity; cation binding; fibroblast growth factor binding; hydrolase activity, hydrolyzing O-glycosyl compounds