Recombinant Human KDR
Cat.No. : | KDR-31717TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 805-1356 of Human VEGF Receptor 2, with an N terminal proprietary tag. |
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Species : | Human |
Tag : | Non |
Protein Length : | 805-1356 a.a. |
Description : | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. |
Biological activity : | 40 U/μg. One unit is defined as the amount of enzyme that will transfer 1 pmol phosphate to Tyr substrate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3 μM Na-orthovanadate, 0.5 mM ATP, 30 μg/ml Poly |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, 10mM Reduced glutathione, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 7 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain. |
Gene Name | KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ] |
Official Symbol | KDR |
Synonyms | KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2; |
Gene ID | 3791 |
mRNA Refseq | NM_002253 |
Protein Refseq | NP_002244 |
MIM | 191306 |
Uniprot ID | P35968 |
Chromosome Location | 4q11-q12 |
Pathway | Angiogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; |
Function | ATP binding; Hsp90 protein binding; growth factor binding; integrin binding; nucleotide binding; |
◆ Recombinant Proteins | ||
KDR-236HAF555 | Active Recombinant Human KDR Protein, Fc-tagged, Alexa Fluor 555 conjugated | +Inquiry |
KDR-31716THAF488 | Recombinant Human KDR Protein, Fc-tagged, Alexa Fluor 488 conjugated | +Inquiry |
KDR-1187C | Recombinant Chicken KDR | +Inquiry |
KDR-240H | Recombinant Human KDR, C13&N15-labeled | +Inquiry |
Kdr-1786M | Recombinant Mouse Kinase Insert Domain Protein Receptor, Fc-His | +Inquiry |
◆ Cell & Tissue Lysates | ||
KDR-1769HCL | Recombinant Human KDR cell lysate | +Inquiry |
KDR-417HCL | Recombinant Human KDR cell lysate | +Inquiry |
KDR-1520MCL | Recombinant Mouse KDR cell lysate | +Inquiry |
Not For Human Consumption!
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