Recombinant Human KAT5 Protein, His-tagged

• Cat.No.: KAT5-099H
• Product Overview: Recombinant N-terminal His-tagged full length human KAT5 protein (2-513) was expressed in Sf21 cells.

Specification

• Description: The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
• Source: Insect cell
• Species: Human
• Tag: His
• Molecular Mass: 60.3 kDa
• Protein length: 2-513
• Purity: ≥50%
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 pmole of methylated peptide per minute at 37 centigrade in 100mM HEPES, pH7.5, 0.8% TritonX-100 containing 100 μM histone H4 peptide (amino acids 1-21), and acetyl-CoA. Activity was determined using a HAT Inhibitor Screening Assay Kit.
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, pH 7.5, with 300 mM sodium chloride and 10% glycerol

Gene Information

• Gene Name: KAT5 lysine acetyltransferase 5 [ Homo sapiens (human) ]
• Official Symbol: KAT5
• Synonyms: KAT5; lysine acetyltransferase 5; TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1; NEDFASB; histone acetyltransferase KAT5; 60 kDa Tat-interactive protein; HIV-1 Tat interactive protein, 60kDa; K(lysine) acetyltransferase 5; K-acetyltransferase 5; Tat interacting protein, 60kDa; cPLA(2)-interacting protein; cPLA2 interacting protein; histone acetyltransferase HTATIP; EC 2.3.1.48
• Gene ID: 10524
• mRNA Refseq: NM_006388
• Protein Refseq: NP_006379
• MIM: 601409
• UniProt ID: Q92993