Recombinant Human Janus Kinase 3, GST-tagged, Active

• Cat.No.: JAK3-337H
• Product Overview: Recombinant human JAK3 (781-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 64 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 781-end a.a.
• Description: JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease. Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow.
• Sequence: 781-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: JAK3 Janus kinase 3 [ Homo sapiens ]
• Synonyms: JAK3; Janus kinase 3; JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; leukocyte Janus kinase; tyrosine-protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); EC 2.7.10.2
• Gene ID: 3718
• mRNA Refseq: NM_000215
• Protein Refseq: NP_000206
• MIM: 600173
• UniProt ID: P52333
• Chromosome Location: 19p13.1
• Pathway: Chemokine signaling pathway; Jak-STAT signaling pathway; Primary immunodeficiency
• Function: ATP binding; Janus kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity