Recombinant Human JAG1, Fc-tagged

• Cat.No.: JAG1-27630TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-1067 of Human Jagged1 fused at the C-terminus to the Fc portion of Human IgG1; MWt 150 kDa .

Specification

• Description: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein.Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch.Mutations that alter the jagged 1 protein cause Alagille syndrome.Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
• Protein length: 1067 amino acids
• Conjugation: Fc
• Molecular Weight: 150.000kDa inclusive of tags
• Source: HEK 293 cells
• Tissue specificity: Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a wh
• Biological activity: Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 DSL domain.Contains 15 EGF-like domains.

Gene Information

• Gene Name: JAG1 jagged 1 [ Homo sapiens ]
• Official Symbol: JAG1
• Synonyms: JAG1; jagged 1; AGS, Alagille syndrome , JAGL1; protein jagged-1; AHD; AWS; CD339; HJ1
• Gene ID: 182
• mRNA Refseq: NM_000214
• Protein Refseq: NP_000205
• Uniprot ID: P78504
• Chromosome Location: 20p12.1-p11.23
• Pathway: Delta-Notch Signaling Pathway, organism-specific biosystem; Notch receptor binds with a ligand, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem
• Function: Notch binding; calcium ion binding; growth factor activity; structural molecule activity