Recombinant Human IRF3 protein, His/sumo-tagged

• Cat.No.: IRF3-62H
• Product Overview: Recombinant Human IRF3(1-452 aa) fused with His/sumo tag was expressed in E. coli.

Specification

• Description: IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.
• Source: E. coli
• Species: Human
• Tag: His&SUMO
• Form: Tris-based buffer,50% glycerol
• Protein length: 1-452 aa
• AA Sequence: MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NSGVGDFSQP DTSPDTNGGG STSDTQEDIL DELLGNMVLA PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT PFPNLGPSEN PLKRLLVPGE EWEFEVTAFY RGRQVFQQTI SCPEGLRLVG SEVGDRTLPG WPVTLPDPGM SLTDRGVMSY VRHVLSCLGG GLALWRAGQW LWAQRLGHCH TYWAVSEELL PNSGHGPDGE VPKDKEGGVF DLGPFIVDLI TFTEGSGRSP RYALWFCVGE SWPQDQPWTK RLVMVKVVPT CLRALVEMAR VGGASSLENT VDLHISNSHP LSLTSDQYKA YLQDLVEGMD FQGPGES
• Purity: >90% ( SDS-PAGE )
• Storage: Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade. Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.

Gene Information

• Gene Name: IRF3 interferon regulatory factor 3 [ Homo sapiens ]
• Official Symbol: IRF3
• Synonyms: IRF3; interferon regulatory factor 3
• Gene ID: 3661
• mRNA Refseq: NM_001197128
• Protein Refseq: NP_001184057
• MIM: 603734
• UniProt ID: Q14653
• Chromosome Location: 19q13.3-q13.4
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Apoptosis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem
• Function: DNA binding; identical protein binding; protein binding; protein homodimerization activity; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; transcription regulatory region DNA binding