Recombinant Human Interleukin 21 Receptor

• Cat.No.: IL21R-1659H

Specification

• Cat. No.: IL21R-1659H
• Description: Interleukin 21 receptor is a type I cytokine receptor. The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-21 R is Mr 51.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 80-85 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
• Tag: Non

Gene Information

• Gene Name: IL21R interleukin 21 receptor [ Homo sapiens ]
• Synonyms: IL21R; interleukin 21 receptor; NILR; MGC10967; IL-21R; Novel interleukin receptor; Interleukin-21 receptor; IL-21R
• Gene ID: 50615
• mRNA Refseq: NM_021798
• Protein Refseq: NP_068570
• MIM: 605383
• UniProt ID: Q9HBE5
• Chromosome Location: 16p11
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: interleukin-21 receptor activity; receptor activity