Recombinant Human Interleukin 17B

• Cat.No.: IL17B-166H
• Product Overview: Recombinant human IL-17B produced inE.coliis a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage.
• Purity: > 98% by SDS-PAGE and HPLC analysis.
• Endotoxin Level: < 0.1 ng per ug of IL-17B.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng.
• Reconstitution: The human IL-17B should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20℃.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20℃. Reconstituted human IL-17B should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: IL17B interleukin 17B [ Homo sapiens ]
• Synonyms: IL17B; interleukin 17B; ZCYTO7; IL-20; Interleukin-17B;IL-17B; Cytokine-like protein Zcyto7; Neuronal interleukin-17-related factor; Interleukin-20; MGC138900; MGC138901; Neuronal interleukin-17-related factor; interleukin-17 beta
• Gene ID: 27190
• mRNA Refseq: NM_014443
• Protein Refseq: NP_055258
• MIM: 604627
• UniProt ID: Q9UHF5
• Chromosome Location: 5q33.1
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity;signal transducer activity