Recombinant Human Interleukin 10, His-tagged

• Cat.No.: IL10-364H
• Product Overview: Human RecombinantInterleukin-10 produced in E. coli is single, a non-glycosylated, Polypeptidechain containing 160 amino acids fragment (19-178) and having a total MW 18.6kDa with an amino-terminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Interleukin-10(IL-10 or IL10), also known as human cytokine synthesis inhibitory factor(CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by theIL10 gene. This cytokine is produced primarily by monocytes and to a lesserextent by lymphocytes. This cytokine has pleiotropic effects inimmunoregulation and inflammation. It down-regulates the expression of Th1cytokines, MHC class II antigens, and costimulatory molecules on macrophages.
• Form: Interleukin-10 Hisis supplied in 1 x PBS and 50% glycerol.
• Purity: Greater than 95.0%as determined by analysis by RP-HPLC and SDS-PAGE.
• Storage: Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
• OfficialSymbol: IL10
• Pathways: Africantrypanosomiasis; Allograft rejection; Amoebiasis; Asthma; Autoimmune thyroiddisease; Chagas disease (American trypanosomiasis); Cytokine-cytokine receptorinteraction; Cytokines and Inflammatory Response; IL4-mediated signalingevents; Intestinal immune network for IgA production; Jak-STAT signalingpathway; Leishmaniasis; Malaria; Pertussis; Regulation of nuclear SMAD2/3signaling

Gene Information

• Gene Name: IL10 interleukin 10 [ Homosapiens ]
• Synonyms: IL10;interleukin 10; CSIF; TGIF; IL-10; IL10A; MGC126450; MGC126451; interleukin-10;OTTHUMP00000034567; T-cell growth inhibitory factor; cytokine synthesisinhibitory factor ; Interleukin-10; Cytokine synthesis inhibitory factor
• Gene ID: 3586
• mRNA Refseq: NM_000572
• Protein Refseq: NP_000563
• MIM: 124092
• UniProt ID: P22301
• Chromosome Location: 1q31-q32
• Function: cytokine activity;growth factor activity; interleukin-10 receptor binding