Recombinant Human IL9, His-tagged

• Cat.No.: IL9-28162TH
• Product Overview: Recombinant full length Human IL9 with His tag produced in the endosperm tissue of barley grain ; 143 amino acids with tag, Predicted MWt 16.2 kDa.

Specification

• Description: The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
• Conjugation: HIS
• Biological activity: Bioactivity is assayed by measuring the dose dependent effect of Human IL9 on proliferation of murine TS1h9RA3 cell line, transfected with Human IL9 receptor (Renauld & Van Snick, Curr. Prot. in Immunol.2002). The ED50 for this batch is 120 pg/ml.
• Form: Lyophilised:Reconstitute the lyophilized protein in sterile water, to a concentration of no less than 100 μg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
• Sequence Similarities: Belongs to the IL-7/IL-9 family.
• Full Length: Full L.

Gene Information

• Gene Name: IL9 interleukin 9 [ Homo sapiens ]
• Official Symbol: IL9
• Synonyms: IL9; interleukin 9; interleukin-9; homolog of mouse T cell and mast cell growth factor 40; HP40; IL 9; P40; p40 cytokine; p40 T cell and mast cell growth factor; T cell growth factor p40
• Gene ID: 3578
• mRNA Refseq: NM_000590
• Protein Refseq: NP_000581
• MIM: 146931
• Uniprot ID: P15248
• Chromosome Location: 5q31-q35
• Pathway: Asthma, organism-specific biosystem; Asthma, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL-9 Signaling Pathway, organism-specific biosystem
• Function: cytokine activity; growth factor activity; interleukin-9 receptor binding