Recombinant Human IL4 Protein
Cat.No. : | IL4-80H |
Product Overview : | IL-4 was produced in E. coli cells transformed with human IL-4 gene. This product is sterile and does not contain any components of animal origin. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Description : | The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
AA Sequence : | HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS |
Purity : | > 95% by SDS-PAGE |
Applications : | Research |
Quality Control Test : | Verified by Mass Spectrometry analyses and disulfide mapping. |
Notes : | For research use only |
Storage : | Avoid repeated freeze-thaw cycles. 12 months at -20 to -80 centigrade. 1 month at 2 to 8 centigrade. |
Concentration : | 1.0 mg/mL |
Storage Buffer : | Sterile filtered through a 0.2 micron filter in 50% glycerol, 10 mM Phosphate buffer at pH 7, 200 mM |
Gene Name | IL4 interleukin 4 [ Homo sapiens (human) ] |
Official Symbol | IL4 |
Synonyms | IL4; interleukin 4; interleukin-4; B cell growth factor 1; B_cell stimulatory factor 1; BCGF 1; BCGF1; BSF1; IL 4; lymphocyte stimulatory factor 1; MGC79402; binetrakin; pitrakinra; IL-4; BSF-1; BCGF-1 |
Gene ID | 3565 |
mRNA Refseq | NM_000589 |
Protein Refseq | NP_000580 |
MIM | 147780 |
UniProt ID | P05112 |
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Not For Human Consumption!
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