Recombinant Human IL22 Protein, His-tagged

• Cat.No.: IL22-217H
• Product Overview: Biotinylated Recombinant Human Interleukin-22 is produced by Human 293 Cells. The target gene encoding A34-I179 is expressed with a 6His tag at the C terminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: 34-179 a.a.
• Description: Interleukin-22 (IL22) is a cytokine that belongs to the IL-10 family or IL-10 superfamily, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 initiated its biological activity by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S1s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut.
• Form: Lyophilized frum a 0.2 um filtered solution of PBS, pH7.2.
• Molecular Mass: Predicted Molecular Weight: 20.8kDa
  Apparent Molecular Weight: Biotinylated IL-22 protein appeared as a smear between 25-40kDa in a reducing SDS-PAGE gel due to glycosylation.
• AA Sequence: A34-I179
• Endotoxin: Less than 0.1 EU/ug.
• Purity: >95%
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
  Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
• Reconstitution: It is not recommended to reconstitute to a concentration less than 100μg/ml.
  Dissolve the lyophilized protein in distilled water.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Quality Statement: Purity: greater than 95% as determined by reducing SDS-PAGE
• Shipping: The product is shipped on dry ice pack.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: IL22 interleukin 22 [ Homo sapiens (human) ]
• Official Symbol: IL22
• Synonyms: Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL22; ZCYTO18; TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
• Gene ID: 50616
• mRNA Refseq: NM_020525.5
• Protein Refseq: NP_065386.1
• MIM: 605330
• UniProt ID: Q9GZX6