Recombinant Human IL1RN, His-tagged
| Cat.No. : | IL1RN-28733TH |
| Product Overview : | Recombinant fusion protein, corresponding to amino acids 26-177 of Human IL1RA (152 amino acids) with an N terminal hexahistidine tag. |
- Specification
- Gene Information
- Related Products
- Download
| Description : | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Conjugation : | HIS |
| Source : | E. coli |
| Tissue specificity : | The intracellular form of IL1RN is predominantly expressed in epithelial cells. |
| Form : | Liquid |
| Purity : | >95% by SDS-PAGE |
| Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Protein length : | 26-177 a.a. |
| Gene Name | IL1RN interleukin 1 receptor antagonist [ Homo sapiens ] |
| Official Symbol | IL1RN |
| Synonyms | IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; |
| Gene ID | 3557 |
| mRNA Refseq | NM_000577 |
| Protein Refseq | NP_000568 |
| MIM | 147679 |
| Uniprot ID | P18510 |
| Chromosome Location | 2q14.2 |
| Pathway | Cytokine Signaling in Immune system, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin-1 signaling, organism-specific biosystem; |
| Function | interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All IL1RN Products
Required fields are marked with *
My Review for All IL1RN Products
Required fields are marked with *
0
Inquiry Basket
