Recombinant Human IL18R1, His-tagged

• Cat.No.: IL18R1-191H
• Product Overview: Recombinant Human IL18R1 /CD218a Protein (rh IL18R1 /CD218a) Ala 19 - Arg 329 (Accession # AAH69575) was produced in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: 19-329 a.a.
• Description: Interleukin-18 receptor 1 (IL18R1) is also known as CD218 antigen-like family member A (CD218a), IL1 receptor-related protein (IL-1Rrp or IL1R-rp), CDw218a, IL18Ra, IL1RRP, which belongs to the interleukin-1 receptor family. IL18R1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL18R1 is receptor for interleukin 18 (IL-18). IL18R1 binds to the agonist leads to the activation of NF-kappa-B, but does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
• Molecular Mass: rh IL18R1 /CD218a is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 36.6 kDa. The predicted N-terminus is Ala 19. DTT-reduced Protein migrates as 60-70 kDa in SDS-PAGE due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg of the rh IL18R1 /CD218a by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
• Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.

Gene Information

• Gene Name: IL18R1 interleukin 18 receptor 1 [ Homo sapiens ]
• Official Symbol: IL18R1
• Synonyms: IL18R1; interleukin 18 receptor 1; interleukin-18 receptor 1; CD218a; IL 1Rrp; IL1RRP; IL-18R1; IL1R-rp; IL-18R-1; cytokine receptor; IL1 receptor-related protein; CD218 antigen-like family member A; IL18RA; CDw218a; IL-1Rrp
• Gene ID: 8809
• mRNA Refseq: NM_003855
• Protein Refseq: NP_003846
• MIM: 604494
• UniProt ID: Q13478
• Chromosome Location: 2q12
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL12 signaling mediated by STAT4, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem
• Function: interleukin-1 receptor activity; receptor activity; transmembrane signaling receptor activity