Recombinant Human IL17RA protein, His-tagged

• Cat.No.: IL17RA-1741H
• Product Overview: Recombinant Human IL17RA aa. (Pro377~Phe534 (Accession # Q96F46)) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Description: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: 22kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Pro377~Phe534
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 6.4.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: IL17RA interleukin 17 receptor A [ Homo sapiens (human) ]
• Official Symbol: IL17RA
• Synonyms: IL17RA; interleukin 17 receptor A; CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R; interleukin-17 receptor A; IL-17 receptor A
• Gene ID: 23765
• mRNA Refseq: NM_001289905.1
• Protein Refseq: NP_001276834.1
• UniProt ID: Q96F46