Recombinant Human IL17A, Fc-tagged

Description :	The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Protein length :	155 amino acids
Conjugation :	Fc
Molecular Weight :	45.000kDa inclusive of tags
Source :	HEK 293 cells
Tissue specificity :	Restricted to activated memory T-cells.
Form :	Liquid
Purity :	>90% by SDS-PAGE
Storage buffer :	Preservative: NoneConstituents: PBS
Storage :	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities :	Belongs to the IL-17 family.

Gene Name	IL17A interleukin 17A [ Homo sapiens ]
Official Symbol	IL17A
Synonyms	IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A;
Gene ID	3605
mRNA Refseq	NM_002190
Protein Refseq	NP_002181
MIM	603149
Uniprot ID	Q16552
Chromosome Location	6p12
Pathway	Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem;
Function	cytokine activity;