Recombinant Human IKBKB, His-S

• Cat.No.: IKBKB-760H
• Product Overview: Recombinant Human IKBKB (amino acids 1-756) was fused at the N-terminus with His•Tag and S•Tag sequences and expressed inS.frugiperdainsect cells.MW = 88 kDa.

Specification

• Species: Human
• Source: S.frugiperda
• Tag: His
• Protein Length: 1-756 a.a.
• Description: IKKβ is the principal kinase responsible for phosphorylating IκBα, the regulatory subunit of NF-κB transcription factor. Phosphorylation of IκBα leads to its ubiquitination and proteasome degradation, which allows results in the rapid translocation of NF-κB to the nucleus and transcriptional activation of NF-κB-dependent genes.
• Purity: ≥80% by SDS-PAGE.
• Form: Liquid. In 50 mM L-Arg, 50 mM L-Glu, 50 mM NaCl, 20 mM HEPES, 2 mM DTT, 1 mM EDTA, 50% glycerol, 0.03% BRIJ 35 Detergent, pH 7.5.
• Specific Activity: ≥50 units/mg protein.
• Unit Definition: One unit is defined as the amount of enzyme that will convert 1 nmol ATP to ADP per min per mg protein at 37°C.
• Storage: ≤ -70℃. Avoid freeze/thaw.

Gene Information

• Gene Name: IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Homo sapiens ]
• Synonyms: IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta; EC 2.7.11.10
• Gene ID: 3551
• mRNA Refseq: NM_001190720
• Protein Refseq: NP_001177649
• MIM: 603258
• UniProt ID: O14920
• Chromosome Location: 8p11.2
• Pathway: Acute myeloid leukemia; Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway; Chagas disease; Chemokine signaling pathway; Chronic myeloid leukemia; Cytosolic DNA-sensing pathway; Epithelial cell signaling in Helicobacter pylori infection; Insulin signaling pathway; MAPK signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Pancreatic cancer; Pathways in cancer; Prostate cancer; RIG-I-like receptor signaling pathway; Shigellosis; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus
• Function: ATP binding; IkappaB kinase activity; identical protein binding; nucleotide binding; protein binding; protein heterodimerization activity; transcription activator activity; transferase activity