Recombinant Human IFNL2, His-tagged

• Cat.No.: IFNL2-5067H
• Product Overview: Recombinant human IFNL2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: IFNL2, also known as Interleukin 28A (IL28A), is a cytokine distantly related to type I interferons and the IL-10 family. Interleukin 28A (IL28A), Interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
• Molecular Mass: 22.1 kDa (198aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSVPVARLH GALPDARGCH IAQFKSLSPQ ELQAFKRAKD ALEESLLLKD CRCHSRLFPR TWDLRQLQVR ERPMALEAEL ALTLKVLEAT ADTDPALVDV LDQPLHTLHH ILSQFRACIQ PQPTAGPRTR GRLHHWLYRL QEAPKKESPG CLEASVTFNL FRLLTRDLNC VASGDLCV
• Purity: >85 % by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: IFNL2 interferon, lambda 2 [ Homo sapiens (human) ]
• Official Symbol: IFNL2
• Synonyms: IFNL2;IL28A; IL-28A;interferon lambda-2;IFN-lambda-2;interleukin-28A;cytokine Zcyto20;interferon lambda 2;interferon-lambda 2;interleukin 28A (interferon, lambda 2)
• Gene ID: 282616
• mRNA Refseq: NM_172138.1
• Protein Refseq: NP_742150.1
• MIM: 607401
• UniProt ID: Q8IZJ0
• Chromosome Location: 19q13.13
• Pathway: Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Type III interferon signaling
• Function: cytokine activity