Recombinant Human IDS therapeutic protein(Idursulfase)

• Cat.No.: IDS-P037H
• Product Overview: Recombinant Human iduronate-2-sulfatase therapeutic protein is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. It is produced by recombinant DNA technology in a human cell line. It is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various cell types. Recombinant Human iduronate-2-sulfatase therapeutic protein is a 525-amino acid glycoprotein with a molecular weight of approximately 76 kilodaltons. The enzyme contains eight asparagine-linked glycosylation sites occupied by complex oligosaccharide structures. The enzyme activity of idursulfase is dependent on the post-translational modification of a specific cysteine to formylglycine.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: It is designed to replace the natural enzyme, increasing catabolism of certain accumulated glycosaminoglycans (GAG), which abnormally accumulate in multiple tissue types in patients with mucopolysaccharidosis II (MPS-II, or Hunter syndrome).
• Molecular Mass: 76 kDa
• AA Sequence: >heavy chainSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPG>light chainNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP
• Endotoxin: < 0.1 EU per μg of the protein
• Purity: >95%
• Alias: IDS; SIDS; MPS2; Idursulfase
• Publications:
  An 19f Nmr Fragment-Based Approach for the Discovery and Development of Brca2-Rad51 Inhibitors to Pursuit Synthetic Lethality in Combination with Parp Inhibition in Pancreatic Cancer (2023)

Gene Information

• Gene Name: IDS iduronate 2-sulfatase [ Homo sapiens ]
• Official Symbol: IDS
• Synonyms: IDS; iduronate 2-sulfatase; SIDS; Hunter syndrome; idursulfase; iduronate 2-sulfatase 14 kDa chain; iduronate 2-sulfatase 42 kDa chain; alpha-L-iduronate sulfate sulfatase; MPS2
• Gene ID: 3423
• mRNA Refseq: NM_000202
• Protein Refseq: NP_000193
• MIM: 300823
• UniProt ID: P22304
• Chromosome Location: Xq27.3-q28
• Pathway: Dermatan sulfate degradation, organism-specific biosystem; Dermatan sulfate degradation, conserved biosystem; Glycosaminoglycan degradation, organism-specific biosystem; Glycosaminoglycan degradation, conserved biosystem; Heparan sulfate degradation, organism-specific biosystem; Heparan sulfate degradation, conserved biosystem; Lysosome, organism-specific biosystem
• Function: catalytic activity; hydrolase activity; iduronate-2-sulfatase activity; metal ion binding; sulfuric ester hydrolase activity