Recombinant Human HTR2A, His-tagged

• Cat.No.: HTR2A-1729H
• Product Overview: Recombinant Human HTR2A produced in E.Colicontains 6*his tag withthe plasmid PET28a.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodesone of the receptors for serotonin, a neurotransmitterwith many roles.Mutations in this gene are associated with susceptibility toschizophrenia and obsessive-compulsive disorder, and arealso associated with response to the antidepressant citalopram in patientswith major depressive disorder (MDD). MDDpatients who also have a mutation in intron 2 of this gene show asignificantly reduced response to citalopram as this antidepressant downregulatesexpression of this gene. Multiple transcript variants encodingdifferent isoforms have been found for this gene.
• Antigenpeptide region: 1-151aa
• StorageBuffer: 1MPBS (58mM Na2HPO4, 17mM NaH2PO4,68mM NaCl, pH8.) added with 300mM Imidazole and 0.7% Sarcosyl, 15% glycerol.
• OfficialSymbol: HTR2A

Gene Information

• Gene Name: HTR2A 5-hydroxytryptamine(serotonin) receptor 2A, G protein-coupled [ Homo sapiens ]
• Synonyms: 5-hydroxytryptamine(serotonin)receptor 2A; HTR2; 5-HT2A; 5-HT2 receptor; Serotonin receptor 2A; 5-hydroxytryptaminereceptor 2A; 5-HT-2; OTTHUMP00000018378; 5-HT-2A; serotonin 5-HT-2A receptor;HTR2A; G protein-coupled
• Gene ID: 3356
• mRNA Refseq: NM_000621
• Protein Refseq: NP_000612
• MIM: 182135
• UniProt ID: P28223
• Chromosome Location: 13q14-q21
• Pathway: GPCR ligand binding; Calcium signaling pathway; Gap junction
• Function: drug binding; receptor activity; serotonin binding