Recombinant Human HSPG2 Protein, His-Tagged

• Cat.No.: HSPG2-03H
• Product Overview: Recombinant human HSPG2 protein, N-His-tagged, was expressed in E. coli cell

Specification

• Description: This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants.
• Source: Escherichia coli
• Species: Human
• Tag: His
• Cytogenetics: 1p36.12
• Refseq Size: 14294
• Refseq ORF: 13176
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Storage Buffer: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
• Storage: Store at -80°C.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Molecular Mass: 27.7 kDa
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: HSPG2 heparan sulfate proteoglycan 2 [ Homo sapiens (human) ]
• Official Symbol: HSPG2
• Synonyms: PLC; SJA; SJS; HSPG; SJS1; PRCAN
• Gene ID: 3339
• mRNA Refseq: NM_001291860.2
• Protein Refseq: NP_001278789.1
• UniProt ID: P98160
• MIM: 142461