Recombinant Human HRAS, GST-tagged

• Cat.No.: HRAS-383H
• Product Overview: Recombinant full-length human RAS was expressed inE. colicells using a N-terminal GST tag. MW = 47 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking. There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types. Other members of the RAS superfamily may also contribute to cancer.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog [ Homo sapiens ]
• Synonyms: v-Ha-ras Harvey rat sarcoma viral oncogene homolog; CTLO; HAMSV; HRAS1; K-RAS; N-RAS; RASH1; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; HRAS; GTPase HRas; OTTHUMP00000162769; OTTHUMP00000166053; OTTHUMP00000166055; p19 H-RasIDX protein; c-has/bas p21 protein; transforming protein p21; Ha-Ras1 proto-oncoprotein; c-ras-Ki-2 activated oncogene; GTP- and GDP-binding peptide B; transformation gene: oncogene HAMSV; Ras family small GTP binding protein H-Ras; H-Ras-1; Ha-Ras; c-H-ras; p21ras
• Gene ID: 3265
• mRNA Refseq: NM_001130442
• Protein Refseq: NP_001123914
• MIM: 190020
• UniProt ID: P01112
• Chromosome Location: 11p15.5
• Pathway: Acute myeloid leukemia; Axon guidance; B cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Endocytosis; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation MAPK signaling pathway; Melanogenesis; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; Thyroid cancer; Tight junction; VEGF signaling pathway
• Function: GTP binding; GTPase activity; nucleotide binding; protein C-terminus binding