Recombinant Human HMGCS2 Protein, His-tagged

• Cat.No.: HMGCS2-134H
• Product Overview: Recombinant Human HMGCS2, transcript variant 2, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 48.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) [ Homo sapiens ]
• Official Symbol: HMGCS2
• Synonyms: HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial); hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
• Gene ID: 3158
• mRNA Refseq: NM_001166107
• Protein Refseq: NP_001159579
• MIM: 600234
• UniProt ID: P54868

Reviews

01/25/2025

HMGCS2-134H

We tested the enzyme and found that it worked. We were able to observe optimal results at the protein concentration of 1 µg/well.