Recombinant Human HEY1, His-tagged

• Cat.No.: HEY1-29230TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-304 of Human HEY1, His-Tag at N-terminus.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-304 a.a.
• Description: This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.
• Conjugation: HIS
• Tissue specificity: Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 0.1% Triton-X-100, 10mM Tris, 10mM DTT, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the HEY family.Contains 1 basic helix-loop-helix (bHLH) domain.Contains 1 Orange domain.
• Full Length: Full L.

Gene Information

• Gene Name: HEY1 hairy/enhancer-of-split related with YRPW motif 1 [ Homo sapiens ]
• Official Symbol: HEY1
• Synonyms: HEY1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; BHLHb31; CHF 2; CHF2; HERP2; HESR 1; HESR1; HRT 1
• Gene ID: 23462
• mRNA Refseq: NM_001040708
• Protein Refseq: NP_001035798
• MIM: 602953
• Uniprot ID: Q9Y5J3
• Chromosome Location: 8q21
• Pathway: Delta-Notch Signaling Pathway, organism-specific biosystem; Heart Development, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem
• Function: DNA binding; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; microsatellite binding; protein binding; protein binding transcription factor activity