Recombinant Human hematopoietic cell-specific Lyn substrate 1 Protein, His&StrepII tagged

• Cat.No.: HCLS1-073H
• Product Overview: Recombinant human HCLS1 protein (P14317) (Asn 213-Ala 428) with a Strep II tag at the N-terminus and a His tag at the C-terminus was expressed in E. coli.

Specification

• Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
• Source: E. coli
• Species: Human
• Tag: N-StrepII and C-His
• Protein length: 213-428aa
• Molecular Mass: 26.7 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: HCLS1 hematopoietic cell-specific Lyn substrate 1 [ Homo sapiens (human) ]
• Official Symbol: HCLS1
• Synonyms: HCLS1; hematopoietic cell-specific Lyn substrate 1; hematopoietic lineage cell-specific protein; cortactin like; CTTNL; HS1; p75; lckBP1
• Gene ID: 3059
• mRNA Refseq: NM_005335
• Protein Refseq: NP_005326
• MIM: 601306
• UniProt ID: P14317