Recombinant Human HDAC7

• Cat.No.: HDAC7-29191TH
• Product Overview: Recombinant fragment of Human HDAC7 expressed in a Baculovirus infected Sf9 cell expression system with N-terminal proprietary tag, 80kDa.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Protein length: 452 amino acids
• Molecular Weight: 80.000kDa inclusive of tags
• Source: Baculovirus
• Biological activity: The Specific activity of HDAC7-29191TH was determined to be 80 RLU/min/ng.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.
• Tag: Non

Gene Information

• Gene Name: HDAC7 histone deacetylase 7 [ Homo sapiens ]
• Official Symbol: HDAC7
• Synonyms: HDAC7; histone deacetylase 7; HDAC7A, histone deacetylase 7A; DKFZP586J0917
• Gene ID: 51564
• mRNA Refseq: NM_001098416
• Protein Refseq: NP_001091886
• MIM: 606542
• Uniprot ID: Q8WUI4
• Chromosome Location: 12q13.1
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Cell cycle, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem
• Function: 14-3-3 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding