Recombinant Human Guanosine Monophosphate Reductase, His-tagged

• Cat.No.: GMPR-1926H
• Product Overview: Recombinant humanGMPR protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography.

Specification

• Species: Human
• Tag: His
• Description: GMPR,also known as guanosine monophosphate reductase, catalyzes the irreversibleNADPH-dependent deamination of GMP to IMP. It functions in the conversion ofnucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, andin maintaining the intracellular balance of A and G nucleotides.
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 40% glycerol, 0.15M NaCl, 1mM DTT.
• Molecular Weight: 39.5 kDa(365aa) confirmed by MALDI-TOF.
• Purity: > 95%by SDS-PAGE
• Concentration: 1 mg/ml(determined by Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPIIVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAVPQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRTKTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE CAGEVIERNGRKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD VENTILDILG GLRSTCTYVG AAKLKELSRRATFIRVTQQH NTVFS
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Metabolism; Metabolism of nucleotides;Purine metabolism; Purine salvage

Gene Information

• Gene Name: GMPR guanosine monophosphatereductase [ Homo sapiens ]
• Official Symbol: GMPR
• Synonyms: GMPR; guanosine monophosphate reductase;GMPR1; GMP reductase 1; guanine monophosphate reductase; guanosinemonophosphate reductase 1; guanosine 5"-monophosphate oxidoreductase 1; EC1.7.1.7
• Gene ID: 2766
• mRNA Refseq: NM_006877
• Protein Refseq: NP_006868
• MIM: 139265
• UniProt ID: P36959
• Chromosome Location: 6p23
• Function: GMP reductase activity; metal ion binding;oxidoreductase activity