Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged

• Cat.No.: GRB2-4847H
• Product Overview: Recombinant full-length human GRB2 was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Cat. No.: GRB2-4847H
• Description: GRB2 is an adaptor protein that is the homolog of the Sem5 gene of C. elegans and Drk gene of Drosophila. GRB2 protein contains one SH2 domain and two SH3 domains and plays a role in growth factor-mediated signal transduction. GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1 thereby mediating the growth factor-induced activation of RAS. GRB2 has been implicated in growth factor regulation of the cytoskeleton and DNA synthesis.
• Applications: Western Blot
• Molecular Weight: 49 kDa
• Expression System: E. coli
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: >95%
• Concentration: 0.2 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Acute myeloid leukemia; Adaptive Immunity Signaling; Alpha6-Beta4 Integrin Signaling Pathway; Angiopoietin receptor Tie2-mediated signaling; Axon guidance; B Cell Receptor Signaling Pathway; BCR signaling pathway; Cell junction organization; Cell junction organization; Chemokine signaling pathway; Dorso-ventral axis formation; Dorso-ventral axis formation; EGFR downregulation; EPHA2 forward signaling; Endometrial cancer; Endometrial cancer

Gene Information

• Gene Name: GRB2 growth factor receptor-bound protein 2 [ Homo sapiens ]
• Official Symbol: GRB2
• Synonyms: GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; growth factor receptor-bound protein 2; HT027; protein Ash; OTTHUMP00000166095; OTTHUMP00000166096; OTTHUMP00000166097; OTTHUMP00000166098; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2
• Gene ID: 2885
• mRNA Refseq: NM_002086
• Protein Refseq: NP_002077
• MIM: 108355
• UniProt ID: P62993
• Chromosome Location: 17q24-q25
• Function: SH3/SH2 adaptor activity; epidermal growth factor receptor binding; insulin receptor substrate binding; phosphoprotein binding; phosphotyrosine binding; protein binding; protein domain specific binding