Recombinant Human GRIA2, His-tagged

• Cat.No.: GRIA2-7955H
• Product Overview: Recombinant Human Glutamate Receptor 2/GLUR2 produced by transfected human cell is a secreted protein with sequence (Asn25 Ala543) of Human GLUR2 fused with a polyhistidine tag at the Cterminus.

Specification

• Description: Glutamate Receptor 2 (GLUR2) is a multipass membrane protein that belongs to the glutamategated ion channel family of the GLUR2 subfamily. GLUR2 is one of the ionotropic glutamate receptors that are sensitive to alphaamino3 hydroxy5methyl4isoxazole propionate (AMPA). Lglutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter Lglutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, it shows resensitization, which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
• Source: HEK293 Cells
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.2
• AA Sequence: NSIQIGGLFP RGADQEYSAF RVGMVQFSTS EFRLTPHIDN LEVANSFAVT NAFCSQFSRG VYAIFGFYD KKSVNTITSF CGTLHVSFIT PSFPTDGTHP FVIQMRPDLK GALLSLVEYY Q WDKFAYLY DSDRGLSTLQ AVLDSAAEKK WQVTAINVGN INNDKKDEMY RSLFQDLELK KE RRVILDC ERDKVNDIVD QVITIGKHVK GYHYIIANLG FTDGDLLKIQ FGGANVSGFQ IVD YDDSLV SKFIERWSTL
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: GRIA2 glutamate receptor, ionotropic, AMPA 2 [ Homo sapiens ]
• Official Symbol: GRIA2
• Synonyms: GRIA2; glutamate receptor, ionotropic, AMPA 2; GLUR2; glutamate receptor 2; GluA2; GLURB; gluR-2; gluR-B; AMPA-selective glutamate receptor 2; HBGR2; GluR-K2
• Gene ID: 2891
• mRNA Refseq: NM_000826
• Protein Refseq: NP_000817
• MIM: 138247
• UniProt ID: P42262
• Chromosome Location: 4q32.1
• Pathway: Activation of AMPA receptors, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Cocaine addiction, organism-specific biosystem
• Function: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; glutamate receptor activity; ion channel activity; kainate selective glutamate receptor activity; receptor activity