Recombinant Human GRB2 Protein, His-GST-tagged

• Cat.No.: GRB2-001H
• Product Overview: Recombinant Human GRB2 Protein (1-217 aa (full-length)) with 6xHis-GST tags was expressed in E. coli.

Specification

• Description: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His&GST
• Molecular Mass: 54.1 kDa
• Protein length: 1-217
• Purity: >95% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB).
• Applications: ELISA, Western Blot, Antibody Production, Protein array
• Quality Control Test: 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST monoclonal and peptide fingerprinting by MALDI-TOF mass spectrometry.
• Storage: Store working aliquots at 4 centigrade for up to one week. For extended storage, conserve at −80 centigrade.
• Expiry: 12 months from the date of purchase, if it is properly stored.
• Storage Buffer: Phosphate-Buffered Saline (PBS), pH 7.4. No preservatives added.
• Shipping: Dry Ice

Gene Information

• Gene Name: GRB2 growth factor receptor bound protein 2 [ Homo sapiens (human) ]
• Official Symbol: GRB2
• Synonyms: GRB2; growth factor receptor bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; growth factor receptor-bound protein 2; HT027; SH2/SH3 adapter; GRB2; abundant SRC homology; epidermal growth factor receptor-binding protein GRB2; epididymis secretory sperm binding protein; growth factor receptor-bound protein 3; protein Ash
• Gene ID: 2885
• mRNA Refseq: NM_002086
• Protein Refseq: NP_002077
• MIM: 108355
• UniProt ID: P62993