Recombinant Human GPI Protein, His-tagged
| Cat.No. : | GPI-009H |
| Product Overview : | Recombinant Human GPI protein (2-558) with a C-terminal His-tag was expressed in E. coli |
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| Description : | This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Molecular Mass : | 66.0 kDa |
| Protein length : | 2-558 |
| Purity : | ≥95% estimated by SDS-PAGE |
| Unit Definition : | One unit is defined as the amount of enzyme required to reduce 1 µmol of NADP + to NADPH per minute at 25 centigrade in 50 mM Triethanolamine, pH 7.6, containing 1 mM MgCl2. |
| Stability : | ≥ 2 years |
| Storage : | -80 centigrade |
| Storage Buffer : | 25 mM Tris-HCl, pH 7.0, 100 mM sodium chloride, and 10% glycerol |
| Shipping : | Dry ice in continental US, may vary elsewhere. |
| Gene Name | GPI glucose-6-phosphate isomerase [ Homo sapiens (human) ] |
| Official Symbol | GPI |
| Synonyms | GPI; glucose-6-phosphate isomerase; AMF; NLK; PGI; PHI; GNPI; SA36; SA-36; glucose-6-phosphate isomerase; autocrine motility factor; hexose monophosphate isomerase; hexosephosphate isomerase; neuroleukin; oxoisomerase; phosphoglucose isomerase; phosphohexomutase; phosphohexose isomerase; phosphosaccharomutase; sperm antigen-36; EC 5.3.1.9 |
| Gene ID | 2821 |
| mRNA Refseq | NM_000175 |
| Protein Refseq | NP_000166 |
| MIM | 172400 |
| UniProt ID | P06744 |
Not For Human Consumption!
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