Recombinant Human GNB1
| Cat.No. : | ADRB2-31550TH |
| Product Overview : | Recombinant full length Human ADBR2 with N terminal FLAG tag and C terminal His tag, fused with Giα2 co-expressed with β 1 and γ 2 in Sf9 insect cells. |
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| Description : | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. |
| Conjugation : | FLAG,His |
| Biological activity : | Activity:3.5-7.7 pmol/mg. |
| Form : | Liquid |
| Storage buffer : | Preservative: NoneConstituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4 |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Tag : | His&Flag |
| Full Length : | Full L. |
| Gene Name | ADRB2 adrenergic, beta-2-, receptor, surface [ Homo sapiens ] |
| Official Symbol | ADRB2 |
| Synonyms | ADRB2; adrenergic, beta-2-, receptor, surface; ADRB2R; beta-2 adrenergic receptor; ADRBR; B2AR; BAR; |
| Gene ID | 154 |
| mRNA Refseq | NM_000024 |
| Protein Refseq | NP_000015 |
| Uniprot ID | P07550 |
| Chromosome Location | 5q31-q32 |
| Pathway | Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; |
| Function | G-protein coupled receptor activity; adenylate cyclase binding; adrenergic receptor activity; beta2-adrenergic receptor activity; dopamine binding; |
Not For Human Consumption!
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