Recombinant Human GNAS Protein, His-tagged
Cat.No. : | GNAS-2754H |
Product Overview : | Recombinant Human GNAS Protein (Gly2-Leu394) with N-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
- Download
Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | Gly2-Leu394 |
Description : | This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 49.2 kDa Accurate Molecular Mass: 50 kDa |
Purity : | > 90% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | 100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name | GNAS GNAS complex locus [ Homo sapiens (human) ] |
Official Symbol | GNAS |
Synonyms | GNAS; GNAS complex locus; AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; PITA3; C20orf45; protein ALEX; protein GNAS; protein SCG6 (secretogranin VI); G protein subunit alpha S; adenylate cyclase-stimulating G alpha protein; alternative gene product encoded by XL-exon; extra large alphas protein; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; secretogranin VI |
Gene ID | 2778 |
mRNA Refseq | NM_000516 |
Protein Refseq | NP_000507 |
MIM | 139320 |
UniProt ID | O95467 |
◆ Recombinant Proteins | ||
GNAS-1423H | Recombinant Human GNAS Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
Gnas-3259M | Recombinant Mouse Gnas Protein, Myc/DDK-tagged | +Inquiry |
GNAS-5336HF | Recombinant Full Length Human GNAS Protein, GST-tagged | +Inquiry |
GNAS-363HFL | Recombinant Full Length Human GNAS Protein, C-Flag-tagged | +Inquiry |
Gnas-1045R | Recombinant Rat GNAS Complex Locus | +Inquiry |
◆ Cell & Tissue Lysates | ||
GNAS-5866HCL | Recombinant Human GNAS 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All GNAS Products
Required fields are marked with *
My Review for All GNAS Products
Required fields are marked with *
0
Inquiry Basket