Recombinant Human Glycogen Synthase Kinase 3 Alpha

• Cat.No.: GSK3A-1133H
• Product Overview: The recombinant GSK3A fusion protein serves as a useful substrate for assaying Akt kinase activity.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: GSK3A is one of the Akt substrates. It can be phosphorylated by Akt at Ser21 of GSK3A or Ser9 of GSK-3β. The phosphorylation of GSK negatively regulates its kinase activity.
• Biological Activity: GSK3A fusion protein at a concentration of 2 µg/20 µl reaction was phosphorylated in an in vitro kinase assay with 200 µM ATP. After 30 minutes incubation at 30°C, phosphorylation was detected by Western blot with phospho-specific GSK3A antibodies.
• Molecular Weight: 37.0 kDa
• Form: Liquid. 2.mg/ml in storage buffer containing 20 mM Tris-HCL (pH 7.5), 50 mM Nacl, 2 mM EDTA, 0.1 Mm DTT, and 50% glycerol.
• Appearance: Liquid
• Storage: -20°C or -70°C.
• Pathways: AKT phosphorylates targets in the cytosol; Activation of Chaperones by IRE1alpha; B Cell Receptor Signaling Pathway; Chemokine signaling pathway; Class I PI3K signaling events mediated by Akt; Diabetes pathways; Dopaminergic synapse; Downstream signaling of activated FGFR; FOXM1 transcription factor network; Glycogen Metabolism; IL-3 Signaling Pathway; IL-5 Signaling Pathway; Insulin Signaling; NGF signalling via TRKA from the plasma membrane; PI-3K cascade

Gene Information

• Gene Name: GSK3A glycogen synthase kinase 3 alpha [ Homo sapiens ]
• Official Symbol: GSK3A
• Synonyms: GSK3A; glycogen synthase kinase 3 alpha; DKFZp686D0638; Glycogen synthase kinase-3 alpha; GSK-3 alpha; EC 2.7.11.26
• Gene ID: 2931
• mRNA Refseq: NM_019884
• Protein Refseq: NP_063937
• MIM: 606784
• UniProt ID: P49840
• Chromosome Location: 19q13
• Function: ATP binding; protein binding; nucleotide binding; transferase activity; glycogen synthase kinase 3 activity; protein kinase A catalytic subunit binding; tau-protein kinase activity