Recombinant Human glycerol-3-phosphate dehydrogenase 2, His-tagged

• Cat.No.: GPD2-106H
• Product Overview: Recombinant Human mGPD comprises a 558 amino acid fragment (43-600) corresponding to the GlpA domain fragment of the mature mGPD protein and is expressed in E. coli with an amino-terminal hexahistidine tag.

Specification

• Cat. No.: GPD2-106H
• Description: Mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) is a Ca2+-sensitive, FAD-binding protein, located on the outer surface of the inner mitochondrial membrane. mGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mGPD. Isoform 1 comprises 727aa residues, whereas isoform 2 lacks 126aa residues of the N-terminus. Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin dependent diabetes mellitus.
• Source: E.coli.
• Purity: >95% by SDS-PAGE
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
• Protein length: 43-600 a.a.

Gene Information

• Gene Name: GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) [ Homo sapiens ]
• Synonyms: GPD2; glycerol-3-phosphate dehydrogenase 2 (mitochondrial); GDH2; GPDM; mGPDH; glycerol-3-phosphate dehydrogenase 2, mitochondrial; EC 1.1.5.3; GDH2; GPD-M; GPDH-M; GPDM; mGPDH; mtGPD; mitochondrial glycerophosphate dehydrogenase.
• Gene ID: 2820
• mRNA Refseq: NM_000408
• Protein Refseq: NP_000399
• MIM: 138430
• UniProt ID: P43304
• Chromosome Location: 2q24.1
• Pathway: Glycerophospholipid metabolism
• Function: calcium ion binding; glycerol-3-phosphate dehydrogenase activity; oxidoreductase activity