Recombinant Human GAD1 Protein

• Cat.No.: GAD1-0009H
• Product Overview: Recombinant Human GAD1 Protein without tag was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Description: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
• Applications: ELISA, CLIA, CG
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Short term (up to 7 days) store at 2–8 centigrade. Long term, store at - 20 centigrade. Avoid multiple freeze/thaw cycles.
• Storage Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH7.4

Gene Information

• Gene Name: GAD1 glutamate decarboxylase 1 [ Homo sapiens (human) ]
• Official Symbol: GAD1
• Synonyms: GAD1; glutamate decarboxylase 1; GAD; SCP; CPSQ1; DEE89; glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD-67; glutamate decarboxylase 1 (brain, 67kDa); EC 4.1.1.15
• Gene ID: 2571
• mRNA Refseq: NM_000817
• Protein Refseq: NP_000808
• MIM: 605363
• UniProt ID: Q99259