Recombinant Human Fyn-Related Kinase, GST-tagged, Active

• Cat.No.: FRK-321H
• Product Overview: Recombinant human FRK (208-end) was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=60kDa.

Specification

• Cat. No.: FRK-321H
• Description: FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo. Overexpression of FRK in beta-cells from the pancreas increases the susceptibility of these cells to beta-cell-toxic events (hallmark of Type I diabetes).
• Source: Sf9 insect cells using baculovirus.
• Sequence: 208-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Protein length: 208-end a.a.

Gene Information

• Gene Name: FRK fyn-related kinase [ Homo sapiens ]
• Synonyms: FRK; fyn-related kinase; GTK; RAK; PTK5; PTK5 protein tyrosine kinase 5; Tyrosine-protein kinase FRK;EC2.7.10.2; FYN-related kinase; Nuclear tyrosine protein kinase RAK
• Gene ID: 2444
• mRNA Refseq: NM_002031
• Protein Refseq: NP_002022
• UniProt ID: P42685
• Chromosome Location: 6q21-q22.3
• MIM: 606573
• Function: ATP binding; growth factor binding; identical protein binding; nucleotide binding; transferase activity; non-membrane spanning protein tyrosine kinase activity