Recombinant Human FYN, GST-tagged, Active

• Cat.No.: FYN-322H
• Product Overview: Recombinant human Full-length FYN A was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=85kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: Fyn A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn has been shown to phosphorylate Dab1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2). The interaction of Fyn and Dab1 regulates the phosphorylation, trafficking, and processing of APP and apoEr2. Fyn expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML). Knockdown of Fyn with shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to imatinib.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: FYN FYN oncogene related to SRC, FGR, YES [ Homo sapiens ]
• Synonyms: FYN oncogene related to SRC, FGR, YES; SLK; SYN; MGC45350; FYN; proto-oncogene tyrosine-protein kinase fyn; src-like kinase; Protooncogene Syn; OTTHUMP00000017917; c-syn protooncogene; src/yes-related novel; tyrosine kinase p59fyn(T); p59-Fyn; protein-tyrosine kinase fyn ; OKT3-induced calcium influx regulator; EC 2.7.10.2; OTTHUMP00000017915; OTTHUMP00000017914; src-like kinase
• Gene ID: 2534
• mRNA Refseq: NM_002037
• Protein Refseq: NP_002028
• UniProt ID: P06241
• Chromosome Location: 6q21
• MIM: 137025
• Pathway: Adherens junction; Axon guidance; Fc epsilon RI signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Prion diseases; T cell receptor signaling pathway
• Function: non-membrane spanning protein tyrosine kinase activity; ATP binding; glycoprotein binding; identical protein binding; manganese ion binding; metal ion binding; nucleotide binding; transferase activity; tubulin binding