Recombinant Human Full Length GJB2

• Cat.No.: GJB2-11453H
• Product Overview: Recombinant Human GJB2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.
• Protein length: 1-226 a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol

Gene Information

• Gene Name: GJB2 gap junction protein, beta 2, 26kDa [ Homo sapiens ]
• Official Symbol: GJB2
• Synonyms: GJB2; gap junction protein, beta 2, 26kDa; DFNA3, DFNB1, gap junction protein, beta 2, 26kD (connexin 26) , gap junction protein, beta 2, 26kDa (connexin 26); gap junction beta-2 protein; connexin 26; CX26; NSRD1; HID; KID; PPK; DFNA3; DFNB1; DFNA3A; DFNB1A
• Gene ID: 2706
• mRNA Refseq: NM_004004
• Protein Refseq: NP_003995
• MIM: 121011
• UniProt ID: P29033
• Chromosome Location: 13q11-q12
• Pathway: Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Gap junction assembly, organism-specific biosystem; Gap junction trafficking, organism-specific biosystem; Gap junction trafficking and regulation, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; Oligomerization of connexins into connexons, organism-specific biosystem; Transport of connexins along the secretory pathway, organism-specific biosystem
• Function: gap junction channel activity