Recombinant Human FRS3, GST-tagged

• Cat.No.: FRS3-1449H
• Product Overview: Recombinant full-length human FRS3 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 87 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: FRS3 or fibroblast growth factor receptor substrate 3 is a peripheral plasma membrane protein that is a substrate for the fibroblast growth factor receptor. During FGF or NGF stimulation, FRS3 becomes tyrosine phosphorylated and then serves as a platform for the recruitment of multiple signaling proteins for activation of the Ras-MAP kinase signaling cascade. FRS3 is mainly expressed in fibroblast and myoblast cell lines and undergo robust tyrosine phosphorylation in response to several mitogenic ligands. Through interaction with Rho family of small GTPases, FRS3 has been implicated in the reorganization of the actin cytoskeleton and subsequent morphological changes in various cells.
• Sequence: Full length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: FRS3 fibroblast growth factor receptor substrate 3 [ Homo sapiens ]
• Synonyms: FRS3; fibroblast growth factor receptor substrate 3; SNT2; FRS2B; SNT-2; FRS2beta; MGC17167; FRS2-beta; FGFR substrate 3; OTTHUMP00000016383; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); OTTHUMP00000039786; FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2
• Gene ID: 10817
• mRNA Refseq: NM_006653
• Protein Refseq: NP_006644
• MIM: 607744
• UniProt ID: O43559
• Chromosome Location: 6p21.1
• Function: fibroblast growth factor receptor binding; insulin receptor binding