Recombinant Human FOXA1

Cat.No. : FOXA1-28105TH
Product Overview : Recombinant full length Human FOXA1; amino acids 1-472, 472 amino acids, Predicted MWt 49.1 kDa.
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Species : Human
Source : E.coli
Tag : Non
Protein Length : 472 amino acids
Description : This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
Molecular Weight : 49.100kDa
Tissue specificity : Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mM HEPES, 5mM Calcium chloride, 3mM DTT, 500 mM L-arginine, 300 mM guanidine-HCl, 5 mM cystamine, 5 mM cysteamine, pH 7.5
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Contains 1 fork-head DNA-binding domain.
Gene Name FOXA1 forkhead box A1 [ Homo sapiens ]
Official Symbol FOXA1
Synonyms FOXA1; forkhead box A1; hepatocyte nuclear factor 3, alpha , HNF3A; hepatocyte nuclear factor 3-alpha;
Gene ID 3169
mRNA Refseq NM_004496
Protein Refseq NP_004487
MIM 602294
Uniprot ID P55317
Chromosome Location 14q12-q13
Pathway Direct p53 effectors, organism-specific biosystem; FOXA transcription factor networks, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem;
Function DNA bending activity; DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; double-stranded DNA binding; protein domain specific binding;

Not For Human Consumption!

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