Recombinant Human FK506 Binding Protein 1A, 12kDa, GST-tagged

• Cat.No.: FKBP1A-4845H
• Product Overview: Recombinant full length human FKBP1A was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: FKBP1A is a member of the immunophilin protein family which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and Rapamycin. FKBP1A interacts with various type I receptors, including the TGF-beta type I receptor and competitive binding assays show that the type I receptor may be a natural ligand for FKBP1A. FKBP1A-deficient mice have normal skeletal muscle but show severe dilated cardiomyopathy and ventricular septal defects that mimick a human congenital heart disorder.
• Applications: Western Blot
• Molecular Weight: 38.3 kDa
• Expression System: E.coli
• Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Purity: > 95 %
• Concentration: 0.2 ug/ul
• Sequences: Full length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: ALK1 pathway; ALK2 signaling events; Alpha-synuclein signaling; Calcium Regulation in the Cardiac Cell
• Full Length: Full L.

Gene Information

• Gene Name: FKBP1A FK506 binding protein 1A, 12kDa [ Homo sapiens ]
• Official Symbol: FKBP1A
• Synonyms: FKBP1A; FK506 binding protein 1A, 12kDa; FKBP1; PKC12; FKBP12; PPIASE; FKBP12C; FK506-binding protein 1A (12kD); Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; EC 5.2.1.8; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; 12 kDa FKBP; FKBP-12; OTTHUMP00000029977; OTTHUMP00000029978; OTTHUMP00000029979; OTTHUMP00000029980; Rotamase; rotamase; FK506-binding protein 1; FK506-binding protein 12; FK506-binding protein, T-cell, 12-kD; peptidyl-prolyl cis-trans isomerase; protein kinase C inhibitor 2; EC=5.2.1.8; 12 kDa FK506-binding protein; FK506-binding protein, T-cell, 12-Kd
• Gene ID: 2280
• mRNA Refseq: NM_000801
• Protein Refseq: NP_000792
• MIM: 186945
• UniProt ID: P62942
• Chromosome Location: 20p13
• Function: FK506 binding; SMAD binding; activin binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; ryanodine-sensitive calcium-release channel activity; signal transducer activity; transforming growth factor beta receptor activity; type I transforming growth factor beta receptor binding