Recombinant Human Fibronectin Leucine Rich TransmemBrane Protein 3, His-tagged

• Cat.No.: FLRT3-3201H
• Product Overview: Recombinant HumanFLRT3(extracellular domain, Met 1-Gly 528), fused with a polyhistidine tag at the C-terminus, was expressed inHuman cells.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Protein Length: 1-528 a.a.
• Description: Leucine-rich repeat transmembrane protein FLRT3, also known as Fibronectin-like domain-containing leucine-rich transmembrane protein 3, and FLRT3, is a single-pass type I membrane protein which belongs to the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT3 contains one fibronectin type-III domain and ten LRR (leucine-rich) repeats and is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. FLRT1, FLRT2 and FLRT3 are members of the FLRT family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. Two alternatively spliced transcript variants encoding the same protein have been described. Paraxial protocadherin (PAPC) and FLRT3 form a functional complex with cadherins and PAPC functions as a molecular "governor" to maintain FLRT3 activity at the optimal level for physiological regulation of C-cadherin adhesion, cell sorting, and morphogenesis.
• Sequences of amino acids: 649aa
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70°C.
• Predicted N terminal: Lys 28
• Molecular Mass: The recombinant human FLRT3 consists of 511 amino acids and has a predicted molecular mass of 58 kDa. The apparent molecular mass of rh FLRT3 is approximately 60-70 KDa in SDS-PAGE under reducing conditions due to glycosylation.
• Formulation: Lyophilized from sterile PBS , pH 7.4
• Purity: > 98 % as determined by SDS-PAGE
• Storage: Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: FLRT3 fibronectin leucine rich transmembrane protein 3 [ Homo sapiens ]
• Synonyms: FLRT3;fibronectin leucine rich transmembrane protein 3; KIAA1469; leucine-rich repeat transmembrane protein FLRT3; leucine-rich repeat transmembrane protein FLRT3; Fibronectin-like domain-containing leucine-rich transmembrane protein 3; UNQ856/PRO1865
• Gene ID: 23767
• mRNA Refseq: NM_013281
• Protein Refseq: NP_037413
• MIM: 604808
• UniProt ID: Q9NZU0
• Chromosome Location: 20p11
• Function: protein binding, bridging; receptor signaling protein activity