Recombinant Human Fibroblast Growth Factor Receptor 1, His-tagged

• Cat.No.: FGFR1-5417H
• Product Overview: Recombinant humanFGFR1 catalytic domain (amino acids 308-731), His-tagged. No special measureswere taken to activate this kinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 308-731 a.a.
• Description: FGFs comprise a family of atleast eighteen structurally realted proteins that are involved in a multitudeof physiological and pathological cellular processes, including cell growth,differentation, angiogenesis, wound healing and tumorgenesis. The biologicalactivities of the FGFs are mediated by a family if type I transmembranetyrosine kinases which undergo dimerization and autophosphorylation afterligand binding.
• Form: Liquid in50 mM Tris, pH 7.5 + 100 mM NaCl + 0.2 mM EDTA + 0.05% Triton X-100 + 5mM DTT+ 50% glycerol.
• Molecular Weight: 50.4 kDa
• Purity: ≥ 90% as determinedby SDS-PAGE analysis
• Specific Activity: 620 nmoleof phosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 2μg/ml.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: FGFR1

Gene Information

• Gene Name: FGFR1 fibroblast growth factorreceptor 1 [ Homo sapiens ]
• Synonyms: FGFR1; fibroblast growth factorreceptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR; N-SAM;FLJ99988; fms-related tyrosine kinase 2; H2; H3; H4; H5; N-SAM; CD331;Pfeiffer syndrome; FGFR-1; bFGF-R; EC 2.7.10.1; Fms-like tyrosine kinase 2;c-fgr; CD_antigen; OTTHUMP00000190881; soluble FGFR1 variant 1; FMS-liketyrosine kinase 2; hydroxyaryl-protein kinase; heparin-binding growth factorreceptor; basic fibroblast growth factor receptor 1; OTTHUMP00000190874;OTTHUMP00000190878; OTTHUMP00000190879; c-fgr; soluble FGFR1 variant 2
• Gene ID: 2260
• mRNA Refseq: NM_015850
• Protein Refseq: NP_056934
• MIM: 136350
• UniProt ID: P11362
• Chromosome Location: 8p11.2-p11.1
• Pathway: Adherens junction; Axonguidance; Developmental Biology; Downstream signaling of activated FGFR; EndochondralOssification; FGF signaling pathway; FGFR ligand binding and activation; FRS2-mediatedcascade; Glypican 1 network; IRS-mediated signalling; Insulin receptorsignalling cascade; L1CAM interactions; MAPK signaling pathway; Melanoma; N-cadherinsignaling events; Negative regulation of FGFR signaling
• Function: ATP binding; fibroblast growthfactor receptor activity; fibroblast growth factor receptor activity; heparinbinding; nucleotide binding; protein binding; receptor activity; transferaseactivity